LIST-S2

LIST-SI predicts the deleteriousness of amino acid mutations in proteomes. Here we provide precomputed predictions of ~115,000 transcriptome protein sequences identified by their UniProt accession number followed by Ensembl ENST id. Prediction scores in the range [0 .. 1], where lower scores indicate more benign and higher indicate deleteriousness effect.

Per Mutation: To obtain LIST-SI prediction for a list of mutations, copy and paste these mutations in the input text box and then click [>>]. Each entry should have the following format: AC_ENST:Pos:RefAA:AlleleAA
  AC_ENST: protein accession_transcripts.
  Pos: protein position.
  RefAA: the reference amino acid at position Pos.
  AlleleAA: the allele amino acid.

Example Input:

A0A0A0MRZ7_ENST00000390268:28:P:G

A0A0A0MRZ7_ENST00000390268:112:Y:F

A0A096LP49-2_ENST00000569961:133:E:K

A0A0J9YX94_ENST00000436629:197:T:K

P07766_ENST00000361763:192:R:T

Output:

A0A0A0MRZ7_ENST00000390268:28:P:G  0.966003

A0A0A0MRZ7_ENST00000390268:112:Y:F  0.717128

A0A096LP49-2_ENST00000569961:133:E:K  0.40256

A0A0J9YX94_ENST00000436629:197:T:K  0.845715

P07766_ENST00000361763:192:R:T  0.907909

Per Protein: One can also visualize/download LIST-SI scores for all possible mutation of a specific protein sequence identified by its accession number and ENST id.
Enter an accession and/or ENST id value under Accession and then select:
Download: to download all scores, or
Matrix: to display an interactive matrix with all possible mutant amino acid scores color coded.
  To zoom in, use the mouse to select the region of interest, then one can zoom out by clicking [Reset zoom].